All Games
- Secret Service
- Seek and Destroy
- Sega Bass Fishing Duel
- Sega Classics Collection
- Sega Genesis Collection
- Sega Soccer Slam
- Sega Superstars Tennis
- Sengoku Anthology
- Sensible Soccer 2006
- Serious Sam: Next Encounter
- Shadow of Ganymede
- Shaman King: Power of Spirit
- Shaun Palmer's Pro Snowboarder
- Shaun White Snowboarding
- Shellshock: Nam '67
- Shepherd's Crossing
- Shinobido: Way of the Ninja
- Shogun's Blade
- Short Track Racing: Trading Paint
- Showdown: Legends of Wrestling
- Shrek SuperSlam
- Shrek: Super Party
- Shrek's Carnival Craze
- Silent Hill 2: Director's Cut
- Silent Scope 3
- Sitting Ducks
- Skate Attack
- Skateboard Madness Xtreme Edition
- Ski & Shoot
- Ski Racing 2005
- Ski Racing 2006
- Ski-doo Snow X Racing
- Sky Surfer
- SkyGunner
- Skyscraper
- Slam Tennis
- Smarties: Meltdown
- Smash Court Tennis Pro Tournament
- Smash Court Tennis Pro Tournament 2
- Sniper Assault
- SNK Arcade Classics Vol. 1
- Snoopy vs. the Red Baron
- Snow Rider
- Snowboard Racer 2
- Soccer America: International Cup
- Soccer Life 2
- Soccer Mania
- Sol Divide
- Sonic Heroes
- Sonic Riders